I had been working on a hybrid-control project using DXL-SDK on an RPi4B via U2D2 while keeping the CM-550 running on its standard tools such as TASK and MicroPython, and I had found that each controller would need its own DXL domain/network (see picture below).
One possible solution which is shown below is to “rewire” the 3-Pin TTL cabling system that connects all the DXL actuators. Interested users can view this video link for more details: