Development of an inexpensive 3D clinostat and comparison with other microgravity simulators using Mycobacterium marinum


A joint group of researchers developed an inexpensive 3D Clinostat that can simulate microgravity for biological experiments. The optimal combination of frame velocities for microgravity simulation was determined through computer modeling, with a combination of inner and outer frame velocities predicted to produce the best results. The 3D clinostat was compared to commercially available microgravity simulators, and it was found that it produced similar results in biofilm experiments and transcriptome changes in bacteria compared to the RPM 2.0 simulator. The study validates the use of the inexpensive 3D clinostat and highlights the importance of testing operating conditions with biological experiments.

3D Clinostat.pdf (3.1 MB)